E3 ubiquitin-protein ligase RNF125; RING finger protein 125; T-cell RING activation protein 1; TRAC-1; RNF125

Function

• E3 ubiquitin-protein ligase
  • E3 ligase proteins mediate ubiquitination & subsequent proteasomal degradation of target proteins
• positive regulator of T-cell activation
• ubiquitin conjugation, 3rd step.

Structure

• contains 1 RING-type zinc finger

Expression

• expressed in lymphoid tissues, including bone marrow, spleen, thymus
• weakly expressed in other tissues
• predominant in the CD4+ & CD8+ T-cells

More general terms

• E3 ubiquitin ligase
• ring finger protein
• myristoylated protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96EQ8.html