E3 ubiquitin-protein ligase TRIM41; tripartite motif-containing protein 41; RING finger-interacting protein with C kinase; RINCK (TRIM41, RINCK)

Function

• functions as an E3 ligase that catalyzes ubiquitin-mediated degradation of protein kinase C
• protein modification; protein ubiquitination
• auto-ubiquitinated
• interacts with PRKCA

Structure

• belongs to the TRIM/RBCC family
• contains 1 B box-type Zn+2 finger
• contains 1 B30.2/SPRY domain
• contains 1 RING-type Zn+2 finger

Compartment

cytoplasm, nucleus

Alternative splicing

named isoforms=4

Expression

• expressed in multiple tissues
• highest levels in heart & skeletal muscle

More general terms

• tripartite motif-containing protein (trim protein)
• phosphoprotein
• E3 ubiquitin ligase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=90933
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:90933
• OMIM: https://mirror.omim.org/entry/610530
• UniProt: http://www.uniprot.org/uniprot/Q8WV44.html