E3 ubiquitin-protein ligase MARCH6 (membrane-associated RING finger protein 6, membrane-associated RING-CH protein VI, MARCH-VI, RING finger protein 176, protein TEB-4, Doa10 homolog, MARCH6, KIAA0597, RNF176, TEB4)

Function

• E3 ubiquitin-protein ligase
• ubiquitin conjugation, 3rd step
• auto-ubiquitinated, which results in proteasomal degradation

Structure

• contains 1 RING-CH-type zinc finger, required for E3 ligase activity

Compartment

endoplasmic reticulum membrane

Alternative splicing

named isoforms=2

Expression

• present in brain

More general terms

• E3 ubiquitin ligase
• ring finger protein
• transmembrane 14 protein

Database

• UniProt: http://www.uniprot.org/uniprot/O60337.html