E3 ubiquitin-protein ligase LINCR (lung-inducible neuralized-related C3CH4 RING domain-containing protein, LINCR)

Function

• E3 ubiquitin-protein ligase
• seems to utilize UBE2E1
• in vitro, generates polyubiquitin chains via non-canonical Lys suggesting that it is not involved in tagging substrates for proteosomal degradation
• protein degradation; protein ubiquitination

Structure

• contains 1 NHR (neuralized homology repeat) domain
• contains 1 RING-type Zn+2 finger

More general terms

• E3 ubiquitin ligase
• ring finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96EH8.html