ubiquitin-protein ligase E3C (UBE3C, UBE3C KIAA0010, KIAA10)

Function

• E3 ubiquitin-protein ligase
• may ubiquitinate itself & promote its own degradation
• interacts with 26S proteasome, CAND2

Structure

• C-terminal is necessary & sufficient for the poly-ubiquitin chain assembly
• contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain
• contains 1 IQ domain

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

• expressed in skeletal muscle > kidney, pancreas

More general terms

• E3 ubiquitin ligase
• zinc finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9690
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9690
• UniProt: http://www.uniprot.org/uniprot/Q15386.html