cullin-associated NEDD8-dissociated protein 2; cullin-associated & neddylation-dissociated protein 2; epididymis tissue protein Li 169; TBP-interacting protein of 120 kD B; TBP-interacting protein 120B; p120 CAND2 (CAND2 KIAA0667 TIP120B)

Function

• assembly of ubiquitin ligase complexes
• modulation of ubiquitination of target proteins
• regulation of transcription (putative)
• binds TBP, CNOT3, UBE3C
• ubiquitinated & targeted for proteasomal degradation

Structure

• belongs to the CAND family
• contains 23 HEAT repeats

Compartment

nucleus

Expression

expressed in epididymis (at protein level)

More general terms

• nuclear protein
• HEAT repeat-containing protein (HEATR)

Additional terms

• cullin
• NEDD8; ubiquitin-like protein Nedd8; neddylin; neural cell expressed developmentally down-regulated protein 8; NEDD-8 (NEDD8)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23066
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23066
• OMIM: https://mirror.omim.org/entry/610403
• UniProt: http://www.uniprot.org/uniprot/O75155.html