E3 ubiquitin-protein ligase RAD18; postreplication repair protein RAD18; hHR18; hRAD18; RING finger protein 73 (RAD18, RNF73)

Function

• E3 ubiquitin-protein ligase
• involved in postreplication repair of UV-damaged DNA
• postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA
• associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono- ubiquitination of DNA-associated PCNA on Lys-164
• has ssDNA binding activity
• protein modification; protein ubiquitination
• interacts with UBE2A & UBE2B
• interacts with HLTF & SHPRH

Structure

• belongs to the RAD18 family
• contains 1 RING-type Zn+2 finger
• contains 1 SAP domain
• contains 1 UBZ-type Zn+2 finger

Compartment

nucleus (putative)

More general terms

• E3 ubiquitin ligase
• nuclear protein
• ring finger protein
• phosphoprotein

Additional terms

• DNA repair

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56852
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56852
• OMIM: https://mirror.omim.org/entry/605256
• UniProt: http://www.uniprot.org/uniprot/Q9NS91.html