SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; helicase-like transcription factor; sucrose nonfermenting protein 2-like 3; DNA-binding protein/plasminogen activator inhibitor 1 regulator; HIP116; RING finger protein 80 (HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1)
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Function
- in contrast with other SMARC proteins, is does not seem to associate with actin or actin related proteins
- instead, it may act as a sequence-specific DNA binding ATPase
- has both helicase & E3 ubiquitin ligase activities
- possesses intrinsic ATP-dependent nucleosome-remodeling activity
- this activity may be required for transcriptional activation or repression of specific target promoters (putative)
- plays a role in error-free postreplication repair of damaged DNA & maintains genomic stability through acting as a ubiquitin ligase for Lys-63-linked polyubiquitination of chromatin-bound PCNA
- protein modification; protein ubiquitination
- binds to SP1 & SP3 independent of DNA
- these interactions may be required for basal transcription of target genes
- interacts with PCNA
- the interaction promotes polyubiquitination of PCNA through association with the UBE2B-RAD18 & UBE2V2-UBE2N ubiquitin ligase complexes
- interacts with RAD18, SHPRH, UBE2V2 & UBE2N
Structure
- belongs to the SNF2/RAD54 helicase family, RAD16 subfamily
- contains 1 helicase ATP-binding domain
- contains 1 helicase C-terminal domain
- contains 1 RING-type Zn+2 finger
Compartment
Alternative initiation
named isoforms=2
Expression
- expressed in brain, heart, kidney, liver, lung, pancreas, placenta & skeletal muscle
Genetics
- subject to frequent epigenetic inactivation by promoter methylation in colon cancer
More general terms
- SWI/SNF-related matrix-associated actin dependent regulator of chromatin subfamily A
- transcription factor (TF)
- DNA-binding protein
- ring finger protein
- phosphoprotein