transcription factor Sp3; stimulatory protein 3 (Sp3, SPR-2)

Function

• transcriptional factor that can act as an activator or repressor, probably in a isoform-specific manner
• binds to GT & GC boxes promoters elements

Structure

• belongs to the Sp1 C2H2-type Zn+2-finger protein family
• contains 3 C2H2-type Zn+2 fingers

Compartment

nucleus

Alternative splicing

• named isoforms=6
• alternative initiation
  • AUA codon is translated into Met & used as a translation initiation site (in vitro)

Expression

• ubiquitously expressed

More general terms

• Sp1 transcription factor family
• C2H2 type zinc finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6670
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6670
• OMIM: https://mirror.omim.org/entry/601804
• UniProt: http://www.uniprot.org/uniprot/Q02447.html