ubiquitin-conjugating protein-E2B (ubiquitin-protein ligase B, ubiquitin carrier protein B, E2-17 kD, RAD6B, HR6B, UBE2B)

Function

• catalyzes covalent attachment of ubiquitin to other proteins
• required for postreplication repair of UV-damaged DNA
• associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA- associated PCNA on Lys-164
• may be involved in neurite outgrowth
• interacts with RAD18 & UBR2
• protein degradation; protein ubiquitinylation

ATP + ubiquitin + protein lysine
              <-->
AMP + diphosphate + protein N-ubiquityllysine

Structure

belongs to the ubiquitin-conjugating enzyme family

Compartment

• cell membrane (putative), nucleus
• in peripheral neurons, expressed both at the plasma membrane & in nuclei (putative)

More general terms

• ubiquitin-conjugating protein E2 (ubiquitin carrier protein)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7320
• OMIM: https://mirror.omim.org/entry/179095
• UniProt: http://www.uniprot.org/uniprot/P63146.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7320