E3 ubiquitin-protein ligase UBR2; N-recognin-2; ubiquitin-protein ligase E3-alpha-2; ubiquitin-protein ligase E3-alpha-II (UBR2 C6orf133 KIAA0349)

Function

• ubiquitin ligase protein, ubiquitin conjugation, 3rd step
• component of the N-end rule pathway
• recognizes & binds to proteins bearing specific amino- terminal residues that are destabilizing according to the N-end rule, leading to ubiquitination & subsequent degradation
• pancreatic homeostasis
• interacts with UBE2B
  • promotes the UBE2B-H2A interaction & ubiquitination of histone H2A by UBE2B & UBR2
• interacts with RECQL4

Structure

• the RING-H2 Zn+2 finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif
• belongs to the UBR1 family
• contains 1 RING-type Zn+2 finger
• contains 1 UBR-type Zn+2 finger

Compartment

• nucleus
• associated with chromatin during meiosis

Alternative splicing

named isoforms=4

Expression

• broadly expressed
• highest expression in skeletal muscle, kidney, pancreas, acinar cells of pancreas, fetal pancreas

More general terms

• nuclear protein
• zinc finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23304
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23304
• OMIM: https://mirror.omim.org/entry/609134
• UniProt: http://www.uniprot.org/uniprot/Q8IWV8.html