ATP-dependent DNA helicase Q4; DNA helicase, recQ-like type 4; recQ4; RTS; recQ protein-like 4 (RECQL4, RECQ4)
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Function
- DNA-dependent ATPase
- may modulate chromosome segregation
- interacts with UBR1 & UBR2
- interacts with MCM10
- interaction regulates RECQL4 unwinding activity
Structure
- belongs to the helicase family, recQ subfamily
- contains 1 helicase ATP-binding domain
- contains 1 helicase C-terminal domain
Compartment
Expression
- ubiquitously expressed
- highest levels in thymus & testis
- up-regulated in actively dividing cells
Pathology
- defects in RECQL4 are a cause of
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/O94761.html
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/RECQL4ID285.html
- ↑ GeneReviews http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/RECQL4
- ↑ NIEHS-SNPs http://egp.gs.washington.edu/data/recql4/
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9401
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9401
- OMIM: https://mirror.omim.org/entry/218600
- OMIM: https://mirror.omim.org/entry/266280
- OMIM: https://mirror.omim.org/entry/268400
- OMIM: https://mirror.omim.org/entry/603780
- UniProt: http://www.uniprot.org/uniprot/O94761.html