protein MCM10 homolog (HsMCM10, MCM10)
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Function
- role in DNA replication (putative)
- role in activation of the pre-replication complex (putative)
- recruited to the replication sites before they replicate & dissociates from chromatin after the activation of the pre-replication complex
- self-associates (putative)
- interacts with ORC2
- may interact with MCM2 & MCM6
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure
- zinc finger-like domain binds Zn+2, involved in self-association (putative)
- belongs to the MCM10 family
Compartment
- nucleus
- colocalizes with ORC2 in nuclei foci
- associated with chromatin in S phase
- fom early to mid-S phase located in discrete nuclear foci
- in early S phase, several hundred foci appeared throughout the nucleus
- in mid-S phase, foci appear at the nuclear periphery & nucleolar regions
- in the late S & G phases, localized to nucleoli
Expression
- cell cycle regulated
- expression increases at the G1/S-boundary
- expression decreases in late M phase, remains low during G1 phase, & starts to accumulate at the onset of S phase