origin recognition complex subunit 2 (ORC2L, ORC2)

Function

• component of the origin recognition complex (ORC) that binds origins of replication.
• role in both chromosomal replication & mating type transcriptional silencing
• binds to the ARS consensus sequence of origins of replication (ATP-dependent)
• interacts with DBF4
• interacts with MCM10

Structure

belongs to the ORC2 family

Compartment

nucleus

More general terms

• protein subunit
• nuclear protein

Component of

• origin of replication complex (origin recognition complex, ORC)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4999
• OMIM: https://mirror.omim.org/entry/601182
• UniProt: http://www.uniprot.org/uniprot/Q13416.html