protein DBF4 homolog (activator of S phase Kinase, DBF4, ASK, dumbell former 4)
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Function
- regulatory subunit for CDC7, activates kinase activity
- required for entry into S phase
- CDC7-DBF4 selectively phosphorylates MCM2 subunit of chromatin-associated MCM complex
- initiation of DNA replication during cell cycle
- forms a complex with CDC7
- interacts with MEN1, MCM2, ORC2, ORC4 & ORC6
Structure
- contains 2 BRCT domains
- contains 1 DBF4-type Zn+2 finger
Compartment
Alternative splicing
named isoforms=2
Expression
- expressed in testis, thymus, most cancer cells lines
- induced in G1 phase at low level, increased during G1-S phase & remains high during S phase & G2-M phase