origin recognition complex subunit 6 (ORC6L, ORC6)

Function

• component of the origin recognition complex (ORC) that binds origins of replication
• role in both chromosomal replication & mating type transcriptional silencing
• binds to the ARS consensus sequence of origins of replication (ATP-dependent)
• interacts with DBF4
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

belongs to the ORC6 family

Compartment

nucleus

More general terms

• protein subunit
• nuclear protein
• phosphoprotein

Component of

• origin of replication complex (origin recognition complex, ORC)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2359
• OMIM: https://mirror.omim.org/entry/607213
• UniProt: http://www.uniprot.org/uniprot/Q9Y5N6.html