cell division cycle 7-related protein kinase; CDC7-related kinase; HsCdc7; huCdc7 (CDC7, CDC7L1)

Function

• seems to phosphorylate critical substrates that regulate the G1/S phase transition &/or DNA replication
• phosphorylates MCM2 & MCM3
• may phosphorylate p34RPA
• forms a complex with either DBF4/DBF4A or DBF4B, leading to activation of the kinase activity

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, Ser/Thr protein kinase family, CDC7 subfamily
• contains 1 protein kinase domain

Compartment

nucleus

Alternative splicing

• named isoforms=1
• a number of isoforms may be produced

Comparative biology

• yeast CDC7 is required in vivo for mutagenic repair in Saccharomyces cerevisiae following exposure to DNA-damaging agents

More general terms

• serine/threonine kinase
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8317
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8317
• OMIM: https://mirror.omim.org/entry/603311
• UniProt: http://www.uniprot.org/uniprot/O00311.html