DNA replication licensing factor MCM3; DNA polymerase alpha holoenzyme-associated protein P1; RLF subunit beta; P102 protein; P1-MCM3 (MCM3)
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Function
- acts as a factor that allows the DNA to undergo a single round of replication per cell cycle
- required for DNA replication & cell proliferation
- phosphorylated upon DNA damage, probably by ATM or ATR
- gene is activated during S-phase & P1 is phosphorylated
Structure
- human P1 protein is a homolog of the yeast Mcm3 (minichromosome maintenance protein)
- belongs to the MCM family
- contains 1 MCM domain
Compartment
- nucleus
- associated with the replication-specific DNA polymerase alpha
- P1 remains in the nucleus during & after S-phase in contrast to yeast Mcm3
More general terms
References
- ↑ Schulte D et al Expression, phosphorylation and nuclear localization of the human P1 protein, a homologue of the yeast Mcm 3 replication protein. J Cell Science 108:1381 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7615659
- ↑ Burkhart R et al Interactions of human nuclear proteins P1Mcm3 and P1Cdc46. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7705359 Eur J Biochem 228:431 1995
- ↑ UniProt http://www.uniprot.org/uniprot/P25205.html
- ↑ NIEHS-SNPs http://egp.gs.washington.edu/data/mcm3/