DNA replication licensing factor MCM6; p105MCM (MCM6)

Function

• may be involved in control of a single round of DNA replication during S phase
• binds to chromatin during G1 phase & detaches from it during S phase as if it licenses the chromatin to replicate
• phosphorylated upon DNA damage, probably by ATM or ATR
• may interact with MCM10
• interacts with TIPIN
• forms a stable trimeric complex with CDC21 & p85MCM.
• protein BM28/Mcm2 is more loosely associated with the trimeric complex

Structure

• belongs to the MCM family
• contains 1 MCM domain

Compartment

• nucleus (putative)

Polymorphism

• intronic variations in MCM6 upstream from the LCT gene are associated with adult-type hypolactasia leading to lactose intolerance, or with lactase persistence
• a non-coding variation in MCM6 affects the transcriptional regulation of the LCT gene resulting in down-regulation of lactase activity

More general terms

• minichromosome maintenance (Mcm) protein
• phosphoprotein

Additional terms

• DNA replication licensing factor MCM3; DNA polymerase alpha holoenzyme-associated protein P1; RLF subunit beta; P102 protein; P1-MCM3 (MCM3)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4175
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4175
• OMIM: https://mirror.omim.org/entry/223100
• OMIM: https://mirror.omim.org/entry/601806
• UniProt: http://www.uniprot.org/uniprot/Q14566.html