DNA replication licensing factor MCM2; minichromosome maintenance protein 2 homolog; nuclear protein BM28 (MCM2 BM28 CCNL1 CDCL1 KIAA0030)

Function

• acts as a factor that allows the DNA to undergo a single round of replication per cell cycle.
• required for the entry in S phase & for cell division
• phosphorylated on Ser-108 by ATR in proliferating cells
• Ser- 108 proliferation is increased by genotoxic agents
• Ser-40 is mediated by the CDC7-DBF4 & CDC7-DBF4B complexes
• Ser-53 phosphorylation is only mediated by the CDC7-DBF4 complex
• interacts with DBF4 (putative)
• interacts with MYST2
• may interact with MCM10

Structure

• belongs to the MCM family
• contains 1 MCM domain

Compartment

nucleus

More general terms

• minichromosome maintenance (Mcm) protein
• zinc finger protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P49736.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4171
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4171
• OMIM: https://mirror.omim.org/entry/116945