ubiquitin-conjugating protein-E2A (ubiquitin-conjugating enzyme E2-17 kD, RAD6A homolog, HR6A, UBE2A)

Function

• catalyzes covalent attachment of ubiquitin to other proteins
• required for postreplication repair of UV-damaged DNA
• interacts with RAD18
• protein degradation; protein ubiquitinylation

ATP + ubiquitin + protein lysine
               <-->
AMP + diphosphate + protein N-ubiquityllysine

Structure

• belongs to the ubiquitin-conjugating enzyme family

More general terms

• ubiquitin-conjugating protein E2 (ubiquitin carrier protein)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7319
• OMIM: https://mirror.omim.org/entry/312180
• UniProt: http://www.uniprot.org/uniprot/P49459.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7319