E3 ubiquitin-protein ligase HECTD1; E3 ligase for inhibin receptor; EULIR; HECT domain-containing protein 1 (HECTD1, KIAA1131)

Function

• probable E3 ubiquitin-protein ligase ubiquitin conjugation, 3rd step
• may be required for development of the head mesenchyme & neural tube closure
• interacts with IGSF1

Structure

• belongs to the UPL family, K-HECT subfamily
• contains 4 ANK repeats
• contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain
• contains 1 MIB/HERC2 domain

More general terms

• E3 ubiquitin ligase
• ankyrin repeat domain protein (ANKRD)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=25831
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:25831
• UniProt: http://www.uniprot.org/uniprot/Q9ULT8.html