E3 ubiquitin-protein ligase RNF123; Kip1 ubiquitination-promoting complex protein 1; RING finger protein 123 (RNF123, KPC1, FP1477)

Function

• catalytic subunit of the KPC complex
• E3 ubiquitin-protein ligase
• poly-ubiquitination & proteasome-mediated degradation of CDKN1B during G1 phase of cell cycle
• ubiquitin conjugation, 3rd step
• interacts with UBADC1 & CDKN1B via its N-terminal domain
• ubiquitinated, leading to its degradation
• deubiquitinated by USP19, stimulating CDKN1B ubiquitin- dependent degradation
• interacts with UBAC1 & CDKN1B via its N-terminal domain

Structure

• contains 1 B30.2/SPRY domain
• contains 1 RING-type Zn+2 finger

Compartment

cytoplasm

Alternative splicing

named isoforms=2

More general terms

• E3 ubiquitin ligase
• enzyme catalytic subunit
• ring finger protein

Component of

• KPC complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=63891
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:63891
• OMIM: https://mirror.omim.org/entry/614472
• UniProt: http://www.uniprot.org/uniprot/Q5XPI4.html