ubiquitin carboxyl-terminal hydrolase 19; deubiquitinating enzyme 19; ubiquitin thiolesterase 19; ubiquitin-specific-processing protease 19; zinc finger MYND domain-containing protein 9 (USP19, KIAA0891, ZMYND9)

Function

• deubiquitinating enzyme
• deubiquitinates & prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation
• role in decreased protein synthesis in atrophying skeletal muscle
• modulates transcription of major myofibrillar proteins
• role in endoplasmic reticulum-associated degradation (ERAD) of substrates
• thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with RNF123 (putative)

Structure

• belongs to the peptidase C19 family
• contains 2 CS domains
• contains 1 MYND-type Zn+2 finger

Compartment

• endoplasmic reticulum membrane
• single-pass membrane protein

Alternative splicing

• named isoforms=4

More general terms

• ubiquitin C-terminal hydrolase
• zinc finger protein
• membrane protein
• phosphoprotein

Additional terms

• ubiquitin (UBCEP2, UBB, UBC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10869
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10869
• UniProt: http://www.uniprot.org/uniprot/O94966.html