E3 ubiquitin-protein ligase RNF138 (RING finger protein 138, Nemo-like kinase-associated RING finger protein, NLK-associated RING finger protein, RNF138, NARF, HSD-4)

Function

• E3 ubiquitin-protein ligase
• with NLK, involved in the ubiquitination & degradation of TCF/LEF
• negative regulator in Wnt/beta-catenin-mediated signaling (putative)
• ubiquitin conjugation, 3rd step
• interacts with the C-terminal region of NLK
• auto-ubiquitinated

Structure

• contains 1 RING-type zinc finger RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme

Alternative splicing

named isoforms=2

More general terms

• E3 ubiquitin ligase
• ring finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8WVD3.html