E3 ubiquitin-protein ligase MARCH8 (membrane-associated RING finger protein 8. membrane-associated RING-CH protein VIII, MARCH-VIII, RING finger protein 178, cellular modulator of immune recognition, c-MIR, MARCH8, MIR, RNF178)

Function

• E3 ubiquitin-protein ligase
• ubiquitin conjugation, 3rd step
• may regulate immune responses by promoting ubiquitination of MHC-2 & CD86, which leads to their subsequent endocytosis & lysosomal degradation
• may also promote ubiquitination & endocytosis of TFRC & FAS
• interacts with CD86

Structure

• contains 1 RING-CH-type zinc finger, required for E3 ligase activity

Compartment

cytoplasmic vesicle membrane

Expression

• broadly expressed
• present in immature dendritic cells (at protein level)

More general terms

• E3 ubiquitin ligase
• ring finger protein
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q5T0T0.html