E3 ubiquitin-protein ligase TRIM50; tripartite motif-containing protein 50 (TRIM50, TRIM50A)

Function

• E3 ubiquitin-protein ligase
• auto-ubiquitinated
• can form dimers & trimers
• interacts with several E2 ubiquitin-conjugating enzymes, including UBE2L6, UBE2E1, UBE2E3
• no interaction with UBE2H

Structure

• belongs to the TRIM/RBCC family
• contains 1 B box-type Zn+2 finger
• contains 1 B30.2/SPRY domain
• contains 1 RING-type Zn+2 finger

Compartment

cytoplasm

Alternative splicing

named isoforms=2; alpha, beta

More general terms

• tripartite motif-containing protein (trim protein)
• E3 ubiquitin ligase
• ring finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=135892
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:135892
• OMIM: https://mirror.omim.org/entry/612548
• UniProt: http://www.uniprot.org/uniprot/Q86XT4.html