ubiquitin-conjugating protein-E2H

Function

• catalyzes covalent attachment of ubiquitin to other proteins
• capable, in vitro, to ubiquitinate histone H2A at Lys-11 & Lys-48
• protein degradation; protein ubiquitinylation

ATP + ubiquitin + protein lysine
           <-->
AMP + diphosphate + protein N-ubiquityllysine

Structure

belongs to the ubiquitin-conjugating enzyme family

Alternative splicing

named isoforms=2

More general terms

• ubiquitin-conjugating protein E2 (ubiquitin carrier protein)
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7328
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7328
• OMIM: https://mirror.omim.org/entry/601082
• UniProt: http://www.uniprot.org/uniprot/P62256.html