ubiquitin-conjugating enzyme E2 E3; UbcH9; ubiquitin carrier protein E3; ubiquitin-conjugating enzyme E2-23 kD; ubiquitin-protein ligase E3 (UBE2E3, UBCE4, UBCH9)

Function

• accepts ubiquitin from the E1 complex & catalyzes its covalent attachment to other proteins
• in vitro catalyzes Lys-11- & Lys-48-, as well as Lys-63-linked polyubiquitination
• participates in regulation of transepithelial Na+ transport in renal cells
• may be involved in cell growth arrest
• protein modification; protein ubiquitination
• the ubiquitin-loaded form interacts specifically with importin-11 (IPO11), leading to its import into the nucleus
• interacts with NEDD4L

Structure

• belongs to the ubiquitin-conjugating enzyme family

Compartment

• nucleus, cytoplasm
• shuttles between the nucleus & cytoplasm (IPO11-dependent)

Expression

• ubiquitously expressed at low levels
• highly expressed in skeletal muscle

More general terms

• ubiquitin-conjugating protein E2 (ubiquitin carrier protein)
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10477
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10477
• OMIM: https://mirror.omim.org/entry/604151
• UniProt: http://www.uniprot.org/uniprot/Q969T4.html