importin 11 (Ran-binding protein 11, RanBP11, IPO11)

Function

• nuclear protein import as nuclear transport receptor
• receptor for nuclear localization signals (NLS) in cargo substrates
• thought to mediate docking of importin/substrate complex to the nuclear pore complex through binding to nucleoporin
• the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism
• at the nucleoplasmic side of the nuclear pore complex, Ran binds to the importin, the importin/substrate complex dissociates & importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran
• directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- & GDP-bound forms of Ran between the cytoplasm & nucleus
• mediates the nuclear import of UBE2E3, & of RPL12 (putative)
• interacts with UBE2E3 & RPL12

Structure

• belongs to the importin beta family
• contains 15 HEAT repeats
• contains 1 importin N-terminal domain

Compartment

cytoplasm, nucleus

More general terms

• importin beta subunit

Additional terms

• importin complex (NLS-binding protein)
• Ran-binding protein M; Ran-binding protein 9; RanBP9; BPM-L; BPM90; RanBPM; RanBP7 (RANBP9, RANBPM)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5119
• UniProt: http://www.uniprot.org/uniprot/Q9UI26.html