CD49c (integrin-alpha 3, VLA-3 alpha chain, galactoprotein-B3, GAPB3, ITGA3)

Function

• heterodimer with integrin beta-1 (VLA-3)
• interacts with HPS5
• isoform alpha-3A, but not isoform alpha-3B, is phosphorylated on Ser
• phosphorylation increases after stimulation by phorbol 12-myristate 13-acetate

Structure

• belongs to the integrin alpha chain family
• contains 7 FG-GAP repeats
• composed of an heavy & a light chain linked by a disulfide bond

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• isoform alpha-3A is widely expressed
• isoform alpha-3B is expressed in brain & heart
• in brain, both isoforms are exclusively expressed on vascular smooth muscle cells
• in heart isoform alpha-3A is strongly expressed on vascular smooth muscle cells; isoform alpha-3B is detected only on endothelial vein cells

More general terms

• integrin-alpha
• glycoprotein
• CD antigen
• Ca+2 binding protein

Component of

• very late antigen 3 (VLA-3, integrin alpha-3/beta-1)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3675
• OMIM: https://mirror.omim.org/entry/605025
• UniProt: http://www.uniprot.org/uniprot/P26006.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3675