bassoon; zinc finger protein 231 (BSN, KIAA0434, ZNF231)

Function

• role in organization of the cytomatrix at the nerve terminals active zone which regulates neurotransmitter release
• seems to act through binding to ERC2/CAST1
• essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses
• role in formation of the retinal photoreceptor ribbon synapses
• interacts with ERC2/CAST1, RIMS1 & UNC13A
• part of a complex consisting of ERC2, RIMS1 & BSN (putative)

Structure

• myristoylated
  • N-terminal myristoylation is not sufficient for presynaptic localization (putative)

Compartment

• cytoplasm, cytoskeleton (putative)
• cell junction, synapse, synaptosome (putative)
• localized to the active zone of presynaptic density

Expression

• exclusively expressed in brain

More general terms

• phosphoprotein
• lipoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8927
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8927
• OMIM: https://mirror.omim.org/entry/604020
• UniProt: http://www.uniprot.org/uniprot/Q9UPA5.html