ERC protein 2 (ERC2, KIAA0378)

Function

• organization of cytomatrix at the nerve terminals active zone (CAZ)
• regulates neurotransmitter release
• acts together with BSN
• recruits liprin-alpha proteins to the CAZ (putative)
• interacts with BSN, ERC1, PPFIA1, PPFIA2, PPFIA3, PPFIA4
• interacts via C-terminus with the PDZ domain of RIMS1
• component of complex consisting of ERC2, RIMS1 & UNC13A

Compartment

• cytoplasm
• in neurons, localized to synapses
• colocalizes with PCLO
• localized to active zone of presynaptic density

Alternative splicing

named isoforms=2

More general terms

• other protein

Database

• UniProt: http://www.uniprot.org/uniprot/O15083.html