Ca+2/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; Cam-PDE 1B; 63 kD Cam-PDE (PDE1B, PDE1B1, PDES1B)

Function

• cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP & cGMP
• preference for cGMP as a substrate
• activated by the binding of calmodulin in the presence of Ca+2

Cofactor:

• binds 2 divalent metal cations per subunit
• site 1 may preferentially bind Zn+2
• site 2 has a preference for Mg+2 &/or Mn+2

Structure

• homodimer (putative)
• belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily

Compartment

cytoplasm

Alternative splicing

named isoforms=2; PDE1B1, PDE1B2

More general terms

• phosphodiesterase 1
• lipoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5153
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5153
• OMIM: https://mirror.omim.org/entry/171891
• UniProt: http://www.uniprot.org/uniprot/Q01064.html