chylomicron
Jump to navigation
Jump to search
Function
- chylomicrons transport dietary fat from intestinal epithelium into the circulation
- chylomicrons are carried by the lymphatics into the thoracic duct & subsequently the jugular vein & plasma
- within the lymphatics, chylomicrons acquire apo C from HDL
- chylomicrons are metabolized in the periphery via lipoprotein lipases, stimulated by apo C2 & inhibited by apo C3
- the chylomicron remnant is rapidly removed in the liver by LRP which recognizes apo E
Structure
- the major fraction of chylomicrons is triglycerides (80-90% of chylomicron weight)
- 1-2% of weight is contributed by apolipoproteins, apo B-48, apo A1, aop A2, apo A4, & apo C.
Expression
- synthesized by & released from intestinal epithelial cells
- the lipid content of chylomicrons is derived predominantly derived from the alimentary tract
More general terms
More specific terms
Additional terms
- CD91, low density lipoprotein (LDL) receptor related protein (LRP) 1, apolipoprotein E [apoE] receptor 1, chylomicron remnant receptor or alpha-2 macroglobulin receptor
- chylomicron retention disease (Anderson disease)