apolipoprotein C3; apo-CIII (APOC3)

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Function

Structure

Compartment

secreted

Expression

  • expressed predominantly in liver & to a lesser degree in intestine

Pathology

Notes

  • constitutes 50% of the protein fraction of VLDL & 2% of that of HDL

More general terms

References

  1. Tietz Textbook of Clinical Chemistry, 2nd ed. Burtis CA & Ashwood ER (eds), WB Saunders Co, Philadelphia PA, 1993, pg 1022
  2. Petersen KF et al Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease. N Engl J Med 2010 Mar 25; 362:1082 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20335584
    Riordan SM and Williams R. Gut flora and hepatic encephalopathy in patients with cirrhosis. N Engl J Med 2010 Mar 25; 362:1140. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20335591
  3. 3.0 3.1 3.2 The TG and HDL Working Group of the Exome Sequencing Project, National Heart, Lung, and Blood Institute. Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease. N Engl J Med. June 18, 2014 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24941081 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1307095
  4. 4.0 4.1 Jorgensen AB et al Loss-of-Function Mutations in APOC3 and Risk of Ischemic Vascular Disease. N Engl J Med. June 18, 2014 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24941082 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1308027

Database