hepatic triglyceride lipase; hepatic triacylglycerol lipase; HL; lipase member C (LIPC, HTGL)
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Function
- hepatic lipase functions to remove chylomicron remnants from circulation
- preferred substrate is phospholipid associated with HDL
- allegedly, activity negatively correlates with HDL levels
- capacity to catalyze hydrolysis of phospholipids, mono-, di-, & triglycerides, & acyl-CoA thioesters
- attachment to cell surface proteoglycan is presumptive, presumed from release into plasma following heparin administration
- contributes to post-heparin lipolytic activity
triacylglycerol + H2O <--> diacylglycerol + a carboxylate
Structure
- belongs to the AB hydrolase superfamily, lipase family
- contains 1 PLAT domain
Compartment
Pathology
- defects in LIPC are the cause of hepatic lipase deficiency
More general terms
References
- ↑ Primary Hyperlipoproteinemias, Steiner & Shafrir (eds), McGraw Hill, NY, 1991, pg 29
- ↑ Brouwer et al Am J Clin Nutr 57:533 1993
- ↑ SHMPD, The Singapore human mutation and polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=LIPC
- ↑ UniProt http://www.uniprot.org/uniprot/P11150.html