intestinal epithelium

^[1]^[2]^[3]

Function

absorption of substances
providing a barrier against harmful substances
control passage of water, various molecules, cells, & organisms from the gut lumen into the tissues & circulation

hyperglycemia makes the gut barrier more permeable to bacterial products & live bacteria^[3]
genetic variants in INAVA (Clorf106) increase risk for inflammatory bowel disease

↑ Wikipedia: Intestinal epithelium https://en.wikipedia.org/wiki/Intestinal_epithelium
↑ Peterson LW, Artis D Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol. 2014 Mar;14(3):141-53. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24566914 https://www.nature.com/articles/nri3608
↑ ^3.0 ^3.1 Mohanan V, Nakata T, Desch AN et al. Clorf106 is a colitis risk gene that regulates stability of epithelial adherens junctions. Science 2018 Mar 9; 359:1161. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29420262
Manfredo Vieira S, Hiltensperger M, Kumar V et al. Translocation of a gut pathobiont drives autoimmunity in mice and humans. Science 2018 Mar 9; 359:1156. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29590047
Thaiss CA, Levy M, Grosheva I et al. Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection. Science 2018 Mar 23; 359:1376. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29519916
Citi S et al. Intestinal barriers protect against disease. Science 2018 Mar 9; 359:1097 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29590026