innate immunity activator protein (INAVA, C1orf106)
Jump to navigation
Jump to search
Function
- required for optimal pattern recognition receptor-induced signaling, cytokine secretion, & bacterial clearance
- in the intestine, regulates adherens junction stability by regulating degradation of CYTH1 & CYTH2 as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes
- stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation
Alternative splicing
named isoforms=2
Expression
- peripheral macrophages
- intestinal myeloid-derived cells
Pathology
- genetic variations in INAVA are associated with an increased risk of inflammatory bowel disease[3]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q3KP66.html
- ↑ Yan J, Hedl M, Abraham C. An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes. J Clin Invest. 2017 Jun 1;127(6):2192-2205. PMID: https://www.ncbi.nlm.nih.gov/pubmed/28436939 Free PMC Article
- ↑ 3.0 3.1 Mohanan V, Nakata T, Desch AN et al C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions. Science. 2018 Mar 9;359(6380):1161-1166. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29420262