amyloid-beta peptide in CSF

^[1]^[2]

Notes

CSF-based estimates of beta-amyloid using adjusted data-driven cutoffs are ~10% higher than PET-based estimates in people without dementia
- results are similar among people with dementia
all CSF amyloid-beta isoforms lower in patients with cerebral amyloid angiopathy than in controls

↑ Jansen WJ, Janssen O, Tijms BM et al Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum JAMA Neurol. 2022;79(3):228-243 PMID: https://www.ncbi.nlm.nih.gov/pubmed/35099509 https://jamanetwork.com/journals/jamaneurology/fullarticle/2788270
↑ De Kort AM et al. Decreased cerebrospinal fluid amyloid beta 38, 40, 42, and 43 levels in sporadic and hereditary cerebral amyloid angiopathy. Ann Neurol 2023 Jan 27; [e-pub] PMID: https://www.ncbi.nlm.nih.gov/pubmed/36707720 https://onlinelibrary.wiley.com/doi/10.1002/ana.26610