amyloid-beta peptide 42 in CSF
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Introduction
also see Tau/Abeta42 in CSF
Clinical significance
- high CSF Abeta42 associated with normal cognition & hippocampal volume despite increasing brain amyloidosis[1]
- decreased CSF Abeta42 associated with higher likelihood of Alzheimer's disease (AD)
- CSF Abeta42 decreased in patients with spontaneous cerebral amyloid angiopathy & Alzheimer's disease vs controls[3]
- CSF Abeta42 decreased in patients with spontaneous cerebral amyloid angiopathy vs Alzheimer's disease[3]
More general terms
Additional terms
- A4 amyloid peptide; beta-peptide
- cerebrospinal fluid
- Tau/Abeta42 in CSF; amyloid-tau neurodegeneration (ATN) profile
Component of
- Tau/Abeta42 in CSF; amyloid-tau neurodegeneration (ATN) profile
- phosphorylated tau/Abeta42 in CSF
- amyloid-beta peptide 40/42 in CSF (Lumipulse G)
References
- ↑ Jump up to: 1.0 1.1 Sturchio A, Dwevedi AK, Young CB et al High cerebrospinal amyloid-beta 42 is associated with normal cognition in individuals with brain amyloidosis. eClinicalMedicine. 2021. June 28 https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(21)00268-6/fulltext
- ↑ Elliott Knapp D Novel Biomarker Found for Alzheimer's Disease. Medscape. January 20, 2022 https://www.medscape.com/viewarticle/966918
Zaretsky DV, Zaretskaia MV, Molkov YI et al Patients with Alzheimer's disease have increased cellular amyloid uptake. medRxiv 2022. Jan 13 https://www.medrxiv.org/content/10.1101/2022.01.12.22269196v1.full - ↑ Jump up to: 3.0 3.1 3.2 De Kort AM et al. Decreased cerebrospinal fluid amyloid beta 38, 40, 42, and 43 levels in sporadic and hereditary cerebral amyloid angiopathy. Ann Neurol 2023 Jan 27; [e-pub] PMID: https://www.ncbi.nlm.nih.gov/pubmed/36707720 https://onlinelibrary.wiley.com/doi/10.1002/ana.26610
- ↑ Jump up to: 4.0 4.1 Jia J et al. Biomarker changes during 20 years preceding Alzheimer's Disease. N Engl J Med 2024 Feb 21; 390:712-722 PMID: https://www.ncbi.nlm.nih.gov/pubmed/38381674 https://www.nejm.org/doi/10.1056/NEJMoa2310168