mesial temporal sclerosis; hippocampal sclerosis
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Etiology
- temporal lobe epilepsy
- vascular risk factors
- more likely to have stroke, hypertension, or microvascular disease than patients with Alzheimer's disease[6]
Epidemiology
Pathology
- dentate gyrus, CA1, CA4 & to a lesser extent CA3 regions of the hippocampus are involved[5]
- subiculum involved[6]
- neuronal cell loss, gliosis & sclerosis
* histopathology images
Clinical manifestations
- complex partial temporal lobe epilepsy[5]
- dementia in the elderly
Radiology
- MRI neuroimaging (images[4][6])
- increased T2 signal
- hippocampal atrophy
Differential diagnosis
More general terms
References
- ↑ Wikipedia: Mesial temporal sclerosis http://en.wikipedia.org/wiki/Mesial_temporal_sclerosis
- ↑ Columbia Dept of Neurosurgery Mesial Temporal Sclerosis http://www.columbianeurosurgery.org/conditions/mesial-temporal-sclerosis/
- ↑ Johns Hopikins Medicine, Neurology and Neurosurgery Mesial Temporal Sclerosis http://www.hopkinsmedicine.org/neurology_neurosurgery/specialty_areas/epilepsy/seizures/causes/mesial_temporal_sclerosis.html
- ↑ 4.0 4.1 Trepeta S and LG Naul Medscope: eMedicine: Imaging in Mesial Temporal Sclerosis http://emedicine.medscape.com/article/342150-overview
- ↑ 5.0 5.1 5.2 Knipe H, Gaillard F (images) Radiopaedia.org: Mesial temporal sclerosis http://radiopaedia.org/articles/mesial-temporal-sclerosis
- ↑ 6.0 6.1 6.2 6.3 6.4 Wikipedia: Hippocampal sclerosis (image) https://en.wikipedia.org/wiki/Hippocampal_sclerosis
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 19. American College of Physicians, Philadelphia 2021