argyrophilic grain disease (AgD)
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Epidemiology
- disorder of the elderly, incidence increases with age
- approximately 5% of all cases of dementia
Pathology
- abundant spindle-shaped argyrophilic grains in neuronal processes
- coiled bodies in oligodendrocytes
- hyperphosphorylated microtubule-associated protein tau largely in limbic regions
- four-repeat (4R) tauopathy, similar to
- progressive supranuclear palsy (PSP)
- corticobasal degeneration (CBD) distinct from Alzheimer's disease (AD) & Pick's disease
Genetics
Clinical manifestations
More general terms
References
- ↑ Probst A, Tolnay M. [Argyrophilic grain disease (AgD), a frequent and largely underestimated cause of dementia in old patients] Rev Neurol (Paris). 2002 Feb;158(2):155-65. Review. French. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11965171
Tolnay M, Clavaguera F. Argyrophilic grain disease: a late-onset dementia with distinctive features among tauopathies. Neuropathology. 2004 Dec;24(4):269-83. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15641585