neurofilament medium polypeptide; NF-M; neurofilament triplet M protein; 160 kD neurofilament protein; neurofilament 3 (NEFM NEF3 NFM)
Jump to navigation
Jump to search
Function
- neurofilament protein
- can form neurofilaments in association with neurofilament L[3]
- role in maintenance of neuronal caliber
- phosphorylated on a number of the Ser in K-S-P repeats
- phosphorylation results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber
- phosphorylation seems to play a major role in functioning of the larger neurofilament polypeptides (NF-M & NF-H); levels of phosphorylation are altered developmentally & coincide with a change in the neurofilament function
Structure
- repeats containing tripeptide K-S-P
- belongs to the intermediate filament family
Laboratory
More general terms
References
- ↑ Alperts et al Molecular Biology of the Cell, Garland Publishing, New York, NY 1989 pg 662
- ↑ Wang KK et al Calmodulin-binding proteins as calpain substrates. Biochem J 262:693 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2556106
- ↑ 3.0 3.1 Cairns NJ, Lee VM, Trojanowski JQ. The cytoskeleton in neurodegenerative diseases. J Pathol. 2004 Nov;204(4):438-49. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15495240
- ↑ UniProt http://www.uniprot.org/uniprot/P07197.html
- ↑ Human intermediate Filament mutation Database http://www.interfil.org