Rho guanine nucleotide exchange factor 3; exchange factor found in platelets & leukemic & neuronal tissues (XPLN, ARHGEF3)

Function

• acts as guanine nucleotide exchange factor (GEF) for RhoA & RhoB GTPases
• interacts with RHOA & RHOB

Structure

• contains 1 DH domain (DBL-homology domain) contains 1 PH domain

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• widely expressed
• expressed in adult brain & skeletal muscle > heart & kidney

More general terms

• rho guanine nucleotide exchange factor

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NR81.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=50650