Rho-related GTP-binding protein RhoF; Rho family GTPase Rif; Rho in filopodia (RHOF, ARHF, RIF)

Function

• plasma membrane-associated small GTPase
• cycles between an active GTP-bound & an inactive GDP-bound state
• role in formation of thin, actin-rich surface projections called filopodia
• functions cooperatively with CDC42 & Rac to generate additional structures, increasing the diversity of actin- based morphology

Structure

belongs to the small GTPase superfamily, Rho family

Compartment

• cell membrane, lipid-anchor, cytoplasmic side (putative)
• cytoplasm, cytoskeleton

Alternative splicing

named isoforms=2

More general terms

• rho subfamily protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54509
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54509
• UniProt: http://www.uniprot.org/uniprot/Q9HBH0.html