macrophage-stimulating protein receptor; MSP receptor; p185-Ron; CDw136; CD136 (MST1R, PTK8, RON)

Function

• receptor for macrophage stimulating protein (MSP)
• has a tyrosine-protein kinase activity
• binds PLXNB1
• associates with & is negatively regulated by HYAL2
• proteolytic processing yields the two subunits
• phosphorylated in response to ligand binding (probable)

Structure

• heterodimer formed of an alpha chain & a beta chain which are disulfide linked
• belongs to the protein kinase superfamily, Tyr protein kinase family
• contains 3 IPT/TIG domains
• contains 1 protein kinase domain
• contains 1 Sema domain

Compartment

membrane

Alternative splicing

named isoforms=2

delta-RON lacks part of the extracellular domain, oligomerizes & is constitutively activated

Expression

keratinocytes & lung

More general terms

• tyrosine kinase receptor (RTK)
• glycoprotein
• CD antigen

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4486
• OMIM: https://mirror.omim.org/entry/600168
• UniProt: http://www.uniprot.org/uniprot/Q04912.html