hyaluronidase-2; hyal-2; hyaluronoglucosaminidase-2; lung carcinoma protein 2; LuCa-2 (HYAL2, LUCA2)

Function

• hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to yield small oligosaccharides
• very low levels of activity
• associates with & negatively regulates MST1R
• random hydrolysis of 1->4-linkages between N-acetyl-beta-D-glucosamine & D-glucuronate residues in hyaluronate

Structure

• belongs to the glycosyl hydrolase 56 family
• contains 1 EGF-like domain

Compartment

cell membrane, GPI-anchor

Expression

• widely expressed
• no expression in adult brain

More general terms

• hyaluronoglucosaminidase; hyaluronidase (HYAL)
• secreted protein
• glypiated protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8692
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8692
• OMIM: https://mirror.omim.org/entry/603551
• UniProt: http://www.uniprot.org/uniprot/Q12891.html