discoidin domain-containing receptor 2; discoidin domain receptor 2; receptor protein-tyrosine kinase TKT; tyrosine-protein kinase TYRO10; neurotrophic tyrosine kinase, receptor-related 3; CD167 antigen-like family member B; CD167b (DDR2, NTRKR3, TKT, TYRO10)

Function

• tyrosine kinase receptor for fibrillar collagen
• mediates fibroblast migration & proliferation
• contributes to cutaneous wound healing (putative)

Structure

• belongs to the protein kinase superfamily, Tyr protein kinase family, insulin receptor subfamily
• contains 1 F5/8 type C domain
• contains 1 protein kinase domain

Compartment

membrane

Expression

• the major 10 kD transcript is expressed in high levels in heart & lung, less in brain, placenta, liver, skeletal muscle, pancreas, & kidney

More general terms

• tyrosine kinase receptor (RTK)
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4921
• OMIM: https://mirror.omim.org/entry/191311
• UniProt: http://www.uniprot.org/uniprot/Q16832.html