tyrosine-protein kinase receptor Tie-1 (TIE1, TIE)

Function

• probable protein tyrosine-kinase transmembrane receptor

Structure

• belongs to the protein kinase superfamily, Tyr protein kinase family, Tie subfamily
• contains 3 EGF-like domains
• contains 3 fibronectin F3 modules
• contains 2 Ig-like C2-type domains (immunoglobulin-like)
• contains 1 protein kinase domain

Compartment

membrane

Expression

• specifically expressed in developing vascular endothelial cells

More general terms

• tyrosine kinase receptor (RTK)
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7075
• OMIM: https://mirror.omim.org/entry/600222
• UniProt: http://www.uniprot.org/uniprot/P35590.html